Ketamine Nasal Spray Compounded
Ketamine Nasal Spray Compounded acts by blocking receptors in the brain called NMDA receptors, which are involved in inhibitory processes. The blockade of these receptors leads to increased mTOR pathway signaling, increased AMPA receptor activation, and increased development and efficacy of synapses in the brain, leading to an anti-depressant effect. Ketamine nasal spray may be used for the treatment of depression that does not respond to other therapies.
effects of Ketamine Nasal Spray Compounded
Browne CA, Lucki I. Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants.
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Ketamine usage for acute pain is indicated as supplement to traditional pain relievers. This mediation is not meant to be used in isolation for pain management. Ketamine’s optimal dose for pain has not yet been established. However, there exists only a narrow window between the optimal dose for pain management and the dose for anesthesia leading to a loss of consciousness.
Ketamine may help with other chronic pain disorders such as:
Pain from reduced blood flow (ischemia) to tissues
Complex regional pain syndrome, which can impact a limb post-injury
Fibromyalgia, which is a type of pervasive musculoskeletal pain, including back pain
Atypical tooth pain
Phantom limb pain experienced after amputation
Post herpetic neuralgia, which is pain in the nerves after the resolution of shingles
Temporomandibular joint (TMJ) pain
There is only moderate evidence for the effectiveness of ketamine in the treatment of chronic pain. However, it does deserve consideration as a third-line agent if the first and second-line agents such as anti-seizure meds, narcotics, and anti-depressants do not sufficiently address the chronic pain.